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微小染色体维持缺陷蛋白9抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
微小染色体维持缺陷蛋白8抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
微小染色体维持缺陷蛋白7抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
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