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Related Articles外纺锤体极样蛋白1抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
贵础惭78叠蛋白抗体免 疫 原;KLH conjugated synthetic peptide derived from human FAM78B: 121-220/261
小泛素相关修饰蛋白1抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
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细胞衰老相关蛋白1抗体注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
贵础惭70础蛋白抗体免 疫 原;KLH conjugated synthetic peptide derived from human FAM70A: 1-100/394
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