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骋蛋白偶联受体搁础叠23抗体
产物名称 | 英文名称 | 货号 |
G蛋白偶联受体RAB23抗体 | RAB23 | GOY-01K0629 |
商品属性：
英文名称: RAB23
中文名:G蛋白偶联受体RAB23抗体
别 名；DKFZp781H0695; HSPC137;
MGC8900; Rab 23; RAB family small GTP binding protein RAB 23; RAB23, member RAS
oncogene family; RAB23_HUMAN; Ras related protein Rab 23; Ras-related protein
Rab-23.
研究领域；染色质和核信号 神经生物学 信号转导 干细胞 G蛋白偶联受体 G蛋白信号
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；23kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human RAB23: 11-100/237
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The Ras-related superfamily of guanine nucleotide
binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies.
Increasing data suggests an important role for Rab proteins in either
endocytosis or in biosynthetic protein transport. The process of transporting
newly synthesized proteins from the endoplasmic reticulum to various stacks
of the Golgi complex and to secretory vesicles involves the movement of
carrier vesicles and requires Rab protein function. Rab proteins are also an
integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237
amino acid member of the Rab family of proteins and localizes to the
cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in
intracellular protein transportation and signal transduction mediated by
small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter
syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition
characterized by obesity, cardiac defects, polysyndactyly and
craniosynostosis. Function: The small GTPases Rab are key regulators of
intracellular membrane trafficking, from the formation of transport vesicles
to their fusion with membranes. Rabs cycle between an inactive GDP-bound form
and an active GTP-bound form that is able to recruit to membranes different
set of downstream effectors directly responsible for vesicle formation,
movement, tethering and fusion. Together with SUFU, prevents nuclear import
of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates
GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic
processing and modulates GLI2 and GLI3 transcription factor activity. Plays a
role in autophagic vacuole assembly, and mediates defense against pathogens,
such as S.aureus, by promoting their capture by autophagosomes that then
merge with lysosomes. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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