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蛋白酶体激活因子笔础28γ抗体
产物名称 | 英文名称 | 货号 |
蛋白酶体激活因子PA28γ抗体 | PSME3 | GOY-01K2099 |
商品属性：
英文名称: PSME3
中文名:蛋白酶体激活因子PA28γ抗体
别 名；PA28G; 11S
regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator
of multicatalytic protease subunit 3; Ki antibody Ki antigen; Ki nuclear
autoantigen; Ki, PA28 gamma; PA28 gamma; PA28gamma; Proteasome (prosome,
macropain) activator subunit 3 (PA28 gamma; Ki); Proteasome (prosome,
macropain) activator subunit 3; Proteasome activator 28 gamma; Proteasome
activator 28 subunit gamma; Proteasome activator complex subunit 3; Proteasome
activator subunit 3; PSME3; PSME3_HUMAN;
研究领域；细胞生物 免疫学 染色质和核信号 信号转导
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应； Rat, (predicted: Human, Mouse, Chicken, Dog, Pig,
Cow, Horse, Rabbit, Sheep, )
产物应用；IHC-P=1:100-500（石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；28kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PSME3: 181-254/254
亚 型；IgG
纯化方法；affinity purified
by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The 26S proteasome is a multicatalytic proteinase
complex with a highly ordered structure composed of 2 complexes, a 20S core
and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical
subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of
7 beta subunits. The 19S regulator is composed of a base, which contains 6
ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10
non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells
at a high concentration and cleave peptides in an ATP/ubiquitin-dependent
process in a non-lysosomal pathway. An essential function of a modified
proteasome, the immunoproteasome, is the processing of class I MHC peptides.
The immunoproteasome contains an alternate regulator, referred to as the 11S
regulator or PA28, that replaces the 19S regulator. Three subunits (alpha,
beta and gamma) of the 11S regulator have been identified. This gene encodes
the gamma subunit of the 11S regulator. Six gamma subunits combine to form a
homohexameric ring. Alternate splicing results in multiple transcript
variants. [provided by RefSeq, May 2012] Subunit of the 11S REG-gamma (also called
PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which
associates with the proteasome. 11S REG-gamma activates the trypsin-like
catalytic subunit of the proteasome but inhibits the chymotrypsin-like and
postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53
interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation
of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis
after DNA damage. May also be involved in cell cycle regulation. Mediates
CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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