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蛋白颁抑制因子抗体
产物名称 | 英文名称 | 货号 |
蛋白C抑制因子抗体 | Protein C inhibitor | GOY-01K2785 |
商品属性：
英文名称: Protein C inhibitor
中文名:蛋白C抑制因子抗体
别 名；Acrosomal serine
protease inhibitor; IPSP; PAI 3; PAI3; PCI; PLANH 3; PLANH3; Plasma serine
protease inhibitor; Plasminogen activator inhibitor 3; Plasminogen activator
inhibitor III; PROCI; Serpin A5; Serpin peptidase inhibitor clade A (alpha 1
antiproteinase antitrypsin) member 5; Serpin peptidase inhibitor clade A member
5; SerpinA5; IPSP_HUMAN.
研究领域；肿瘤 心血管 免疫学 细胞凋亡
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；43kDa
细胞定位；细胞浆 细胞膜 细胞外基质 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Protein C inhibitor: 251-350/406
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Protein C Inhibitor (PCI), a member of the serine
protease inhibitor (serpin) superfamily, is abundant in plasma and other body
fluids. Protein C Inhibitor inhibits a number of "arginine
specific" serine proteases of the coagulation and fibrinolytic systems
(including thrombin, trypsin, and activated Protein C), as well as plasma and
tissue kallikreins and the sperm protease acrosin. This inhibition is
regulated by glycosaminoglycans, such as heparin and heparan sulphate, and
several polyanions. As well as its roles in the regulation of hemostasis and
fertilisation, Protein C Inhibitor is involved in cell inflammation,
proliferation, apoptosis, tumour cell migration, invasion, and metastasis.
Recent studies have demonstrated an association between Protein C Inhibitor
and multiple sclerosis lesions. Heparin-dependent serine protease inhibitor acting
in body fluids and secretions. Inactivates serine proteases by binding
irreversibly to their serine activation site. Involved in the regulation of
intravascular and extravascular proteolytic activities. Plays hemostatic
roles in the blood plasma. Acts as a procoagulant and proinflammatory factor
by inhibiting the anticoagulant activated protein C factor as well as the
generation of activated protein C factor by the thrombin/thrombomodulin
complex. Acts as an anticoagulant factor by inhibiting blood coagulation
factors like prothrombin, factor XI, factor Xa, plasma kallikrein and
fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators.
In seminal plasma, inactivates several serine proteases implicated in the
reproductive system. Inhibits the serpin acrosin; indirectly protects
component of the male genital tract from being degraded by excessive released
acrosin. Inhibits tissue-and urinary-type plasminogen activator,
prostate-specific antigen and kallikrein activities; has a control on the
sperm motility and fertilization. Inhibits the activated protein C-catalyzed
degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during
the process of transfer of spermatozoa from the male reproductive tract into
the female tract. In urine, inhibits urinary-type plasminogen activator and
kallikrein activities. Inactivates membrane-anchored serine proteases
activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen
activator-dependent tumor cell invasion and metastasis. May also play a
non-inhibitory role in seminal plasma and urine as a hydrophobic hormone
carrier by its binding to retinoic acid. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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