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多核苷酸磷酸化酶蛋白抗体
产物名称 | 英文名称 | 货号 |
多核苷酸磷酸化酶蛋白抗体 | PNPT1 | GOY-01K0336 |
商品属性：
英文名称: PNPT1
中文名:多核苷酸磷酸化酶蛋白抗体
别 名；OLD35; PNPASE;
PNPase 1; Polynucleotide phosphorylase like protein; Polyribonucleotide
nucleotidyltransferase 1, mitochondrial; PNPT1_HUMAN.
研究领域；细胞生物 细胞凋亡 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Cow, Horse, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；81kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PNPT1: 551-650/783
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
PNPT1 is a subunit of the exosome complex, which
is involved in 3-prime-to-5-prime exoribonuclease activity for RNA processing
and degradation. It contains one KH domain and one S1 motif domain. RNA-binding protein implicated in numerous RNA
metabolic processes. Hydrolyzes single-stranded polyribonucleotides
processively in the 3'-to-5' direction. Mitochondrial intermembrane factor
with RNA-processing exoribonulease activity. Component of the mitochondrial
degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA
with a 3'-to-5' directionality in an ATP-dependent manner. Required for
correct processing and polyadenylation of mitochondrial mRNAs. Plays a role
as a cytoplasmic RNA import factor that mediates the translocation of small RNA
components, like the 5S RNA, the RNA subunit of ribonuclease P and the
mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays
a role in mitochondrial morphogenesis and respiration; regulates the
expression of the electron transport chain (ETC) components at the mRNA and
protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating
mRNA degradation activity; degrades c-myc mRNA upon treatment with
IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the
stability of specific mature miRNAs in melanoma cells; specifically and
selectively degrades miR-221, preferentially. Plays also a role in RNA cell
surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of
ribonuclease P, MRP RNA and miR-221 microRNA. Subunit: Homotrimer; in free form. Homooligomer. Component
of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer
containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with TCL1A;
the interaction has no effect on PNPT1 exonuclease activity. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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