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黑色素聚集激素/黑色素富集激素惭颁贬抗体
产物名称 | 英文名称 | 货号 |
黑色素聚集激素/黑色素富集激素MCH抗体 | PMCH | GOY-01K2606 |
商品属性：
英文名称: PMCH
中文名:黑色素聚集激素/黑色素富集激素MCH抗体
别 名；Melanin
concentrating hormone;PMCH; MCH_HUMAN; Pro MCH; Pro melanin concentrating
hormone.
研究领域；细胞生物 神经生物学 信号转导 生长因子和激素
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；16kDa
细胞定位；分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PMCH: 147-165/165
亚 型；IgG
纯化方法；affinity purified
by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
This gene encodes a soluble luminal protein with
two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a
complex with LAMN1 (lectin mannose binding protein 1; also known as ERGIC-53)
that facilitates the transport of coagulation factors V (FV) and VIII (FVIII)
from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic
reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene
cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive
bleeding disorder characterized by mild to moderate bleeding and coordinate
reduction in plasma FV and FVIII levels. This protein has also been shown to
maintain stem cell potential in adult central nervous system and is a marker
for testicular germ cell tumors. The 3' UTR of this gene contains a
transposon-like human repeat element named 'THE 1'. A processed RNA
pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results
in multiple transcript variants encoding distinct isoforms. [provided by
RefSeq, Jun 2010] MCH inhibits ACTH secretion at the end of the
light on period which corresponds to the peak of the circadian rhythm in
ACTH. Inhibits also stress induced ACTH release during the light off period
of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array
of neuronal functions. Stimulates sexual behavior when injected into the
ventromedial nucleus, this effect is antagonized by NEI. In the medial
preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory
effect of melanotropin alpha on exploration behavior. NEI can influence differentiation of neuronal
processes in brain neurons. Affects the content of neurofilament protein in
neuritogenesis (in vitro). May also be a neuromodulatory factor. In
behavioral tests, it stimulates exploration and anxiety when injected into
the ventromedial nucleus. Also stimulates grooming, locomotion and rearing.
May antagonize the inhibitory effect of mch on ACTH release. Reduces dopamine
and dopac release in the ventromedial nucleus. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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