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蛋白激酶C zeta 抗体
产物名称 | 英文名称 | 货号 |
蛋白激酶C zeta 抗体 | PKC zeta | GOY-01K0681 |
商品属性：
英文名称: PKC zeta
中文名:蛋白激酶C zeta 抗体
别 名；AI098070;
aPKCzeta; C80388; EC 2.7.11.13; KPCZ_HUMAN; nPKC zeta; nPKC-zeta;
OTTHUMP00000001368; OTTHUMP00000044160; PKC 2; PKC ZETA; PKC2; Pkcz; PKCZETA;
PKM-zeta, included; PRKCZ; Protein kinase C zeta; Protein kinase C zeta form;
Protein kinase C zeta type; r14-3-3; R74924; zetaPKC; PKC-ZETA; PKC2;
nPKC-zeta.
研究领域；细胞生物 免疫学 神经生物学 信号转导 转录调节因子 激酶和磷酸酶
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；66kDa
细胞定位；细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PKC zeta: 61-160/592
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Protein kinase C (PKC) zeta is a member of the PKC
family of serine/threonine kinases which are involved in a variety of
cellular processes such as proliferation, differentiation and secretion.
Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta
exhibits a kinase activity which is independent of calcium and diacylglycerol
but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC
inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC
isoenzymes, it has only a single zinc finger module. These structural and
biochemical properties indicate that the zeta subspecies is related to, but
distinct from other isoenzymes of PKC. Alternative splicing results in
multiple transcript variants encoding different isoforms. [provided by
RefSeq, Jul 2008]. Calcium- and diacylglycerol-independent
serine/threonine-protein kinase that functions in phosphatidylinositol
3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade,
and is involved in NF-kappa-B activation, mitogenic signaling, cell
proliferation, cell polarity, inflammatory response and maintenance of
long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in
macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate
MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation.
Required for insulin-dependent activation of AKT3, but may function as an
adapter rather than a direct activator. Upon insulin treatment may act as a
downstream effector of PI3K and contribute to the activation of translocation
of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in
adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5
independently of its kinase activity and can activate JUN promoter through
MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling
and activation of |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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