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磷酸化活化复制因子2重组兔单克隆抗体
产物名称 | 英文名称 | 货号 |
磷酸化活化复制因子2重组兔单克隆抗体 | phospho-ATF2 (Thr71) | GOY-01K4403 |
商品属性：
英文名称: phospho-ATF2 (Thr71)
中文名:磷酸化活化复制因子2重组兔单克隆抗体
别 名；ATF2(T71); ATF2
(phospho T71 + T53); phospho-ATF2(Thr53)(mo); ATF2 (phospho T71); p-ATF2
(phospho T71); ATF2 (phospho Thr71); p-ATF2 (phospho Thr71); CREB 2; HB
16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response
Element Binding Protein 2; cAMP response element binding protein CRE BP1;
cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding
protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent
transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.
产物类型；磷酸化抗体 重组兔单抗
研究领域；细胞生物 转录调节因子 表观遗传学
抗体来源；Rabbit
克隆类型；Monoclonal
克 隆 号7B1
交叉反应；Human,
Mouse, Rat,
产物应用；WB=1:500-1000
IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理论分子量；54kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthesised phosphopeptide derived from human ATF2 around the
phosphorylation site of Thr71: TP(p-T)PT
亚 型；IgG
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产物介绍:
ATF2 is a member of the ATF/CREB family of basic
region leucine zipper DNA binding proteins that regulates transcription by
binding to a consensus cAMP response element (CRE) in the promoter of various
viral and cellular genes. Many of these genes are important in cell growth
and differentiation, and in stress and immune responses. ATF2 is a nuclear
protein that binds DNA as a dimer and can form dimers with members of the
ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer
with cJun than as a homodimer. Several isoforms of ATF2 arise by differential
splicing. The stable native full length ATF2 is transcriptionally inactive as
a result of an inhibitory direct intramolecular interaction of its carboxy
terminal DNA binding domain with the amino terminal transactivation domain.
Following dimerization ATF2 becomes a short lived protein that undergoes
ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent
mechanism. Stimulation of the transcriptional activity of ATF2 occurs
following cellular stress induced by several genotoxic agents, inflammatory
cytokines, and UV irradiation. This activation requires phosphorylation of
two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase.
ATF2 is abundantly expressed in brain. Function: Transcriptional activator, probably constitutive,
which binds to the cAMP-responsive element (CRE) (consensus:
5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular
promoters. Interaction with JUN redirects JUN to bind to CRES preferentially
over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as
part of an ATF2/JUN complex. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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