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p400蛋白抗体
产物名称 | 英文名称 | 货号 |
p400蛋白抗体 | p400 | GOY-01K4160 |
商品属性：
英文名称: p400
中文名:p400蛋白抗体
别 名；CAG repeat
protein 32; CAGH32; DKFZP434I225; Domino homolog; E1A binding protein p400; EP
400; EP400; FLJ42018; FLJ45115; hDomino; KIAA1498; KIAA1818; p400 kDa SWI2/SNF2
related protein; P400 SWI2/SNF2-related protein; TNRC12; Trinucleotide repeat
containing 12; Trinucleotide repeat containing gene 12 protein; EP400_HUMAN.
研究领域；肿瘤 细胞生物 免疫学 转录调节因子 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；344kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human p400: 1051-1250/3159
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
NuAR is a multi-protein histone acetyltransferase
complex that functions to acetylate the nucleosomal Histones H4 and H2A,
thereby activating transcription of select target genes. p400, also known as
EP400 (E1A binding protein p400) or mDomino, localizes to the nucleus and is
a component of the NuAR complex. Expressed in brain, liver, thymus, lung,
spleen, colon and kidney, p400 regulates the transcriptional activity of
proteins such as MZF-1 and contributes to the ATPase and helicase activities
of NuA4. p400 is a SWI2/ SNF2-related protein that can interact with the
adenovirus oncoprotein E1A, thus activating the proapoptotic activity of E1A.
The ability of p400 to regulate transcriptional and apoptotic activity
suggests that the NuAR complex may be a crucial component of cell proliferation,
transformation and, possibly, carcinogenesis. Five isoforms of p400 exist due
to alternative splicing events. Component of the NuA4 histone acetyltransferase
complex which is involved in transcriptional activation of select genes
principally by acetylation of nucleosomal histones H4 and H2A. This
modification may both alter nucleosome - DNA interactions and promote
interaction of the modified histones with other proteins which positively
regulate transcription. May be required for transcriptional activation of
E2F1 and MYC target genes during cellular proliferation. The NuA4 complex
ATPase and helicase activities seem to be, at least in part, contributed by
the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42
transcription activity. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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