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中性鞘磷脂2抗体
产物名称 | 英文名称 | 货号 |
中性鞘磷脂2抗体 | NSMase2 | GOY-01K2270 |
商品属性：
英文名称: NSMase2
中文名:中性鞘磷脂2抗体
别 名；N-SMase2; Cca1;
neutral sphingomyelinase 2; Confluent 3Y1 cell-associated protein 1; Neutral
sphingomyelinase 2; Neutral sphingomyelinase II; NSMA2_HUMAN; nSMase-2;
nSMase2; Smpd3; Sphingomyelin phosphodiesterase 3.
研究领域；细胞生物 神经生物学 脂蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；71kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human NSMase2: 511-610/655
亚 型；IgG
纯化方法；affinity
purified by Protein A
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
N-SMase2 (neutral sphingomyelinase 2), also known
as NSMASE2 or SMPD3 (sphingomyelin phosphodiesterase 3), is a ubiquitously
expressed 655 amino acid member of the magnesium-dependent phosphohydrolase
protein family. Localized to the membrane of the Golgi apparatus, N-SMase2
functions to catalyze the hydrolysis of sphingomyelin to form ceramide and
phosphocholine—two proteins that mediate cell
growth arrest and apoptosis. N-SMase2 is enzymatically activated by
unsaturated fatty acids and phosphatidylserine and, through regulation of
ceramide synthesis, is involved in growth suppression and postnatal
development. Expression of N-SMase2 is upregulated during the G0/G1 phases of
the cell cycle and optimal N-SMase2 activity occurs at a slightly basic pH of
7.5. N-SMase2 deficiency is the cause of chondrodysplasia, a genetic disorder
characterized by impaired bone growth that leads to short stature, bowlegs
and underdeveloped joints. Function: Catalyzes the hydrolysis of sphingomyelin to form
ceramide and phosphocholine. Ceramide mediates numerous cellular functions,
such as apoptosis and growth arrest, and is capable of regulating these 2
cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates
the cell cycle by acting as a growth suppressor in confluent cells. Probably
acts as a regulator of postnatal development and participates in bone and
dentin mineralization. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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