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泛素样蛋白NEDD8抗体
产物名称 | 英文名称 | 货号 |
泛素样蛋白NEDD8抗体 | NEDD8 | GOY-01K2066 |
商品属性：
英文名称: NEDD8
中文名:泛素样蛋白NEDD8抗体
别 名；NED8; NEDD 8;
Neddylin; Neural precursor cell expressed developmentally down regulated 8;
Neural precursor cell expressed developmentally down regulated gene 8; Rub1;
Ubiquitin like protein Nedd 8; Ubiquitin like protein Nedd8.
研究领域；肿瘤 免疫学 神经生物学 信号转导 转录调节因子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；8.5kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human NEDD8: 31-81/81
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This product
as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Ubiquitin like proteins fall into two classes: the
first class, ubiquitin-like modifiers (UBLs) function as modifiers in a
manner analogous to that of ubiquitin. Examples of UBLs are SUMO, Rub1 (also
called Nedd8), Apg12 and Hub1. Proteins of the second class include Parkin,
RAD23 and DSK2, are designated ubiquitin domain proteins (UDPs). These
proteins contain domains that are related to ubiquitin but are otherwise
unrelated to each other. In contrast to UBLs, UDPs are not proteolytically
processed or conjugated to other proteins. Rub1 and the corresponding human
homolog NEDD8 are activated by the E1 ubiquitin activating enzyme UBA2, that
forms isopeptide linkages between thio esters. NEDD8 shows 80% homology to
ubiquitin. The best known targets of Rub1 modification are members of the
cullin family. Cullins are subunits of an E3 ubiquitin ligase complex called
the Skp1 /Cul1/Cdc53 F box (SCF). The SCF promotes transfer of ubiquitin from
a ubiquitin conjugating enzyme (E2) to the target protein. Rub1 modification
may regulate SCF function or localization. Ubiquitin-like protein which plays an important
role in cell cycle control and embryogenesis. Covalent attachment to its
substrates requires prior activation by the E1 complex UBE1C-APPBP1 and
linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates
their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination
and proteasomal degradation of cyclins and other regulatory proteins. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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