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贰3泛素连接酶狈贰顿顿4结合蛋白1抗体
产物名称 | 英文名称 | 货号 |
E3泛素连接酶NEDD4结合蛋白1抗体 | N4BP1 | GOY-01K5825 |
商品属性：
英文名称: N4BP1
中文名:E3泛素连接酶NEDD4结合蛋白1抗体
别 名；FLJ31821;
KIAA0615; MGC176730; N4BP1; N4BP1_HUMAN; NEDD4 binding protein 1; NEDD4-binding
protein 1.
研究领域；细胞生物 转录调节因子 表观遗传学 泛素
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；100kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human N4BP1: 531-630/896
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
N4BP1 is an 896 amino acid protein that belongs to
the N4BP1 family. N4BP1 primarily localizes to nucleolus, however it also
localizes to PML nuclear bodies when desumoylated. Detected in heart, lung,
brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary,
N4BP1 is phosphorylated upon DNA damage probably by ATM or ATR. N4BP1
interacts with Nedd4, a protein with a wide range of activities including
modification of ubiquitin-protein ligase, regulation of membrane channels and
potentiating hormone-dependent activation of transcription. N4BP1 inhibits
the E3 ubiquitin-protein ligase ITCH, by interacting with the second WW
domain of ITCH thereby competing with ITCH's substrates and impairing
ubiquitination of substrates. N4BP1 has no obvious transmembrane regions,
which raises the possibility that N4BP1 represents a soluble adaptor that
could sequester ITCH within the cytosol. The N4BP1 gene maps to chromosome
16q12.1. Function: Inhibitor of the E3 ubiquitin-protein ligase ITCH.
Acts by interacting with the second WW domain of ITCH, leading to compete
with ITCH's substrates and impairing ubiquitination of substrates. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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