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粘蛋白-1抗体
产物名称 | 英文名称 | 货号 |
粘蛋白-1抗体 | MUC1 | GOY-01K0091 |
商品属性：
英文名称: MUC1
中文名:粘蛋白-1抗体
别 名；KL-6; MUC-1;
MUC-1/SEC; MUC-1/X; MUC1/ZD; Breast carcinoma associated antigen DF3; CA 15 3;
CA15-3; CA15-3 antigen; CA15.3; CA-153; Carcinoma associated mucin; CD 227;
CD227; CD227 antigen; DF3 antigen; EMA; Episialin; Epithelial membrane antigen;
Epithelial mucin tandem repeat sequence; H23 antigen; H23AG; HGNC:7508; MAM6;
MUC 1; MUC-1; Mucin 1; Mucin 1 precursor; Mucin1; Peanut reactive urinary
mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; Tumor associated
epithelial membrane antigen; Tumor associated mucin
研究领域；肿瘤 免疫学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；Human,
Mouse, Rat,
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；20/138kDa
细胞定位；细胞核 细胞浆 细胞膜 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human MUC1: 1101-1255/1255
<Cytoplasmic>
亚 型；IgG2b
纯化方法；affinity
purified by Protein A
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
MUC1 is a large cell surface mucin glycoprotein
expressed by most glandular and ductal epithelial cells and some
hematopoietic cell lineages. It is expressed on most secretory epithelium,
including mammary gland and some hematopoietic cells. It is expressed
abundantly in lactating mammary glands and overexpressed abundantly in
>90% breast carcinomas and metastases. Transgenic MUC1 has been shown to
associate with all four cebB receptors and localize with erbB1 (EGFR) in
lactating glands. The MUC1 gene contains seven exons and produces several
different alternatively spliced variants. The major expressed form of MUC1
uses all seven exons and is a type 1 transmembrane protein with a large
extracellular tandem repeat domain. The tandem repeat domain is highly O
glycosylated and alterations in glycosylation have been shown in epithelial
cancer cells. Function: The alpha subunit has cell adhesive properties.
Can act both as an adhesion and an anti-adhesion protein. May provide a
protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain
which is involved in cell signaling, through phosphorylations and
protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B
pathways. In activated T-cells, influences directly or indirectly the
Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated
transcription and determines cell fate in the genotoxic stress response.
Binds, together with KLF4, the PE21 promoter element of TP53 and represses
TP53 activity. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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