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基质金属蛋白酶28抗体
产物名称 | 英文名称 | 货号 |
基质金属蛋白酶28抗体 | MMP-28 | GOY-01K0515 |
商品属性：
英文名称: MMP-28
中文名:基质金属蛋白酶28抗体
别 名；Epilysin; Matrix
Metalloproteinase 28; MM 28; MM28; MMP 28; MMP-28; MMP28.
研究领域；肿瘤 免疫学 信号转导
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Guinea Pig, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；44kDa
细胞定位；细胞外基质 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human MMP28: 201-300/520
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Matrix Metalloproteinase 28, also known as
epilysin, was first cloned from human skin keratinocytes and described to
reflect its role in the remodeling of the epidermis. It was found in testis,
as well as heart, brain, placenta, lung, prostate, intestine, and colon.
MMP28 was later cloned from human lung and found in lung, kidney, brain,
skeletal muscle, and several tumor cell lines. At least three MMP28
transcripts of 2.6, 2.0, and 1.2 kb have been reported possibly representing
alternatively spliced forms of MMP28. There are two human sequences (isoform1
and isoform 2) which encode proteins of 520 and 393 amino acids with
predicted masses of 58.9 and 44.5 kDa respectively. The mouse sequence
contains two inserts of 41 and 39 amino acids respectively, relative to the
human sequence. Mouse epilysin has a predicted molecular mass of approx. 70
kDa. Mouse and human epilysin are highly conserved and share 97% identical
residues. Epilysin (MMP-28) contains the key domains of the other MMPs: a
signal peptide, conserved cysteine-containing prodomain (with a furin
cleavage site), conserved histidine-containing catalytic domain, hinge
domain, and hemopexin domain. MMP28 has a furin cleavage site, similar to
MMP11, and is cleaved by the prohormone convertase family of enzymes.
Sequence identity between MMP28 and the other MMPs is low overall. MMP28 is
most closely related to MMP19 (39% sequence identity). Recombinant MMP28
degrades casein. Can degrade casein. Could play a role in tissues
homeostasis and repair. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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