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尝滨狈7叠蛋白抗体
产物名称 | 英文名称 | 货号 |
LIN7B蛋白抗体 | LIN7B | GOY-01K5593 |
商品属性：
英文名称: LIN7B
中文名:LIN7B蛋白抗体
别 名；hVeli2; hLin7B;
hVeli2; Lin 7 homolog B C elegans; LIN 7B; Lin 7b protein likely ortholog of
mouse LIN 7B mammalian LIN 7 protein 2; Lin-7B; LIN7B; LIN7B_HUMAN; MALS 2; MALS-2;
MALS2; Mammalian lin seven protein 2; Mammalian lin-seven protein 2; Protein
lin 7 homolog B; Protein lin-7 homolog B; VELI 2; Veli-2; VELI2; Vertebrate lin
7 homolog 2; Vertebrate lin-7 homolog 2.
研究领域；细胞生物 免疫学 神经生物学 信号转导 细胞粘附分子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Horse, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；23kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human LIN7B: 1-100/207
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Velis are a family of small synaptic proteins that
interact with other proteins at the post-synaptic density (PSD) of neuronal
synapses. Velis contain the PDZ motif involved in recruiting cell adhesion
molecules, receptors, and channels. Veli1 (also designated Lin-7-B and
MALS-1), Veli2 (also designated Lin-7A and MALS-2), and Veli3 (also
designated Lin-7C and MALS-3) are mammalian homologs of C. elegans LIN-7.
Veli proteins are ubiquitously expressed with high expression in brain,
liver, and testis. Velis are localized at the synaptic junctions in neurons.
Velis bind to CASK, a neurexin-binding protein highly concentrated in synapses,
and Mint1, a binding partner with a vesicle trafficking protein. Plays a role in establishing and maintaining the
asymmetric distribution of channels and receptors at the plasma membrane of
polarized cells. Forms membrane-associated multiprotein complexes that may
regulate delivery and recycling of proteins to the correct membrane domains.
The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and
APBA1 may have the potential to couple synaptic vesicle exocytosis to cell
adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of
the NMDA receptor) to neuronal postsynaptic density and may function in
localizing synaptic vesicles at synapses where it is recruited by
beta-catenin and cadherin. Required to localize Kir2 channels, GABA
transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the
basolateral membrane of epithelial cells. May increase the amplitude of ACCN3
acid-evoked currents by stabilizing the channel at the cell surface. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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