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致死因子恶性脑瘤样蛋白1抗体
产物名称 | 英文名称 | 货号 |
致死因子恶性脑瘤样蛋白1抗体 | L3MBTL1 | GOY-01K0826 |
商品属性：
英文名称: L3MBTL1
中文名:致死因子恶性脑瘤样蛋白1抗体
别 名；H-L(3)MBT;
H-l(3)mbt protein; KIAA0681; L(3)mbt protein homolog; L(3)mbt-like; L3MBT;
L3MBTL1; Lethal(3)malignant brain tumor-like protein 1; Lethal(3)malignant
brain tumor-like protein; LMBL1_HUMAN; RGD1307316.
研究领域；肿瘤 神经生物学 转运蛋白 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Horse, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；84kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human L3MBTL1: 551-650/752
亚 型；IgG
纯化方法；affinity
purified by Protein A
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
This gene represents a polycomb group gene. The
encoded protein functions to regulate gene activity, likely via chromatin
modification. The encoded protein may also be necessary for mitosis.
Alternatively spliced transcript variants encoding different isoforms have
been identified.[provided by RefSeq, Sep 2010] Function: Polycomb group (PcG) protein that specifically
recognizes and binds mono- and dimethyllysine residues on target proteins,
therey acting as a 'reader' of a network of post-translational modifications.
PcG proteins maintain the transcriptionally repressive state of genes: acts
as a chromatin compaction factor by recognizing and binding mono- and
dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and
histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin
and repress transcription. Recognizes and binds p53/TP53 monomethylated at
'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and
binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated
repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells,
suggesting that it is required to accomplish normal mitosis. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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