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碍笔狈础5蛋白抗体
产物名称 | 英文名称 | 货号 |
KPNA5蛋白抗体 | KPNA5 | GOY-01K5134 |
商品属性：
英文名称: KPNA5
中文名:KPNA5蛋白抗体
别 名；IMA5_HUMAN;
Importin alpha 6; Importin subunit alpha 6; Importin subunit alpha-6; IPOA 6;
IPOA6; Karyopherin alpha 5; Karyopherin alpha 5 importin alpha 6; Karyopherin
subunit alpha 5; Karyopherin subunit alpha-5; KPNA 5; KPNA5; SRP 6; SRP6.
研究领域；细胞生物 信号转导
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；IHC-P=1:100-500
IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other
applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；52kDa
细胞定位；细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KPNA5: 1-100/538
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The transport of molecules between the nucleus and
the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex
(NPC) which consists of 60-100 proteins and is probably 120 million daltons
in molecular size. Small molecules (up to 70 kD) can pass through the nuclear
pore by nonselective diffusion; larger molecules are transported by an active
process. Most nuclear proteins contain short basic amino acid sequences known
as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin
alpha protein family and is thought to be involved in NLS-dependent protein
import into the nucleus. [provided by RefSeq, Jul 2008] Functions in nuclear protein import as an adapter
protein for nuclear receptor KPNB1. Binds specifically and directly to
substrates containing either a simple or bipartite NLS motif. Docking of the
importin/substrate complex to the nuclear pore complex (NPC) is mediated by
KPNB1 through binding to nucleoporin FxFG repeats and the complex is
subsequently translocated through the pore by an energy requiring, Ran-dependent
mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta
and the three components separate and importin-alpha and -beta are
re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases
Ran from importin. The directionality of nuclear import is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of
Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1
homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of
STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus
nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of
human cytomegalovirus UL84 by recognizing a non-classical NLS. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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