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核蛋白相互作用蛋白2抗体
产物名称 | 英文名称 | 货号 |
核蛋白相互作用蛋白2抗体 | KPNA2 | GOY-01K0278 |
商品属性：
英文名称: KPNA2
中文名:核蛋白相互作用蛋白2抗体
别 名；IMA2_HUMAN;
Importin alpha 1; Importin alpha 2; Importin alpha 2 subunit; Importin alpha
P1; Importin subunit alpha-2; IPO A1; IPOA 1; IPOA1; Karyopherin alpha 2;
Karyopherin alpha 2 RAG cohort 1; Karyopherin alpha 2 subunit; Karyopherin
subunit alpha-2; KPNA 2; KPNA2; KPNA2 protein; Pendulin; QIP 2; QIP2; RAG
cohort 1; RAG cohort protein 1; RCH 1; RCH1; SRP 1; SRP1 alpha; SRP1;
SRP1-alpha; SRP1alpha.
研究领域；细胞生物 染色质和核信号 信号转导
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；58kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KPNA2: 1-100/529
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The import of proteins into the nucleus is a
process that involves at least 2 steps. The first is an energy-independent
docking of the protein to the nuclear envelope and the second is an
energy-dependent translocation through the nuclear pore complex. Imported
proteins require a nuclear localization sequence (NLS) which generally
consists of a short region of basic amino acids or 2 such regions spaced
about 10 amino acids apart. Proteins involved in the first step of nuclear
import have been identified in different systems. These include the Xenopus
protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive
mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the
NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T
antigen and may be involved in the nuclear transport of proteins. KPNA2 also
may play a role in V(D)J recombination [provided by RefSeq, Jul 2008] Functions in nuclear protein import as an adapter
protein for nuclear receptor KPNB1. Binds specifically and directly to
substrates containing either a simple or bipartite NLS motif. Docking of the
importin/substrate complex to the nuclear pore complex (NPC) is mediated by
KPNB1 through binding to nucleoporin FxFG repeats and the complex is
subsequently translocated through the pore by an energy requiring,
Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to
importin-beta and the three components separate and importin-alpha and -beta
are re-exported from the nucleus to the cytoplasm where GTP hydrolysis
releases Ran from importin. The directionality of nuclear import is thought to
be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of
Ran between the cytoplasm and nucleus. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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