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钾通道四聚体结构域蛋白11抗体
产物名称 | 英文名称 | 货号 |
钾通道四聚体结构域蛋白11抗体 | KCTD11 | GOY-01K2246 |
商品属性：
英文名称: KCTD11
中文名:钾通道四聚体结构域蛋白11抗体
别 名；C17orf36; MGC
129844; Potassium channel tetramerisation domain containing 11; REN; Retinoic
acid EGF NGF induced gene protein; C 17 orf 36; KCD11_HUMAN.
研究领域；肿瘤 细胞生物 神经生物学 信号转导 通道蛋白 跨膜蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；26kDa
细胞定位；细胞核 细胞浆 细胞外基质 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KCTD11: 31-130/232
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The KCTD11 gene encodes a protein that has been
identified as a suppressor of Hedgehog signaling. Its inactivation might lead
to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma.
Plays a role as a marker and a regulator of neuronal differentiation;
Up-regulated by a variety of neurogenic signals, such as retinoic acid,
epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis,
growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B.
Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity
of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on
cell proliferation and differentiation by affecting the nuclear transfer of
transcrition factor GLI1, thus maintaining cerebellar granule cells in
undifferentiated state. Plays a role as a marker and a regulator of
neuronal differentiation; Up-regulated by a variety of neurogenic signals,
such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth
factor. Induces apoptosis, growth arrest and the expression of
cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor
and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as
an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal
degradation. Functions as antagonist of the Hedgehog pathway on cell
proliferation and differentiation by affecting the nuclear transfer of
transcrition factor GLI1, thus maintaining cerebellar granule cells in
undifferentiated state, this effect probably occurs via HDAC1
down-regulation, keeping GLI1 acetylated and inactive. When knock-down,
Hedgehog antagonism is impaired and proliferation of granule cells is
sustained. Activates the caspase cascade. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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