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础型流感病毒贬5狈1神经氨酸酶1抗体
产物名称 | 英文名称 | 货号 |
A型流感病毒H5N1神经氨酸酶1抗体 | Influenza A Neuraminidase 1 | GOY-01K2542 |
商品属性：
英文名称: Influenza A Neuraminidase 1
中文名:A型流感病毒H5N1神经氨酸酶1抗体
别 名；NRAM_I97A1; H5N1
Neuraminidase 1.
研究领域；细菌及病毒
抗体来源；Rabbit
克隆类型；Polyclonal
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；49kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from Influenza A H5N1 Neuraminidase 1:
301-400/450
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Influenza A virus is a major public health threat,
killing more than 30,000 people per year in the USA (1). Novel influenza
virus strains emerge periodically to which humans have little or no immunity,
resulting in devastating pandemics. Influenza A can exist in a variety of
animals; however it is in birds that all subtypes can be found (2). These
subtypes are classified based on the combination of the virus coat
glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During
1997, an H5N1 avian influenza virus was determined to be the cause of death
in 6 of 18 infected patients in Hong Kong (3). There was some evidence of
human to human spread of this virus, but it is thought that the transmission
efficiency was fairly low (4). Although it has been known that cleavage site
and glycosylation patterns of the HA protein play important roles in
determining the pathogenicity of H5 avian influenza viruses, it has only
recently been shown that an additional glycosylation site within the globular
head of the NA protein also contributes to the high virulence of the H5N1 virus
(5). Function: Catalyzes the removal of terminal sialic acid
residues from viral and cellular glycoconjugates. Cleaves off the terminal
sialic acids on the glycosylated HA during virus budding to facilitate virus
release. Additionally helps virus spread through the circulation by further
removing sialic acids from the cell surface. These cleavages prevent
self-aggregation and ensure the efficient spread of the progeny virus from
cell to cell. Otherwise, infection would be limited to one round of replication.
Described as a receptor-destroying enzyme because it cleaves a terminal
sialic acid from the cellular receptors. May facilitate viral invasion of the
upper airways by cleaving the sialic acid moities on the mucin of the airway
epithelial cells. Likely to plays a role in the budding process through its
association with lipid rafts during intracellular transport. May additionally
display a raft-association independent effect on budding. Plays a role in the
determination of host range restriction on replication and virulence.
Sialidase activity in late endosome/lysosome traffic seems to enhance virus
replication. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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