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白细胞介素27β抗体
产物名称 | 英文名称 | 货号 |
白细胞介素27β抗体 | IL-27beta | GOY-01K1128 |
商品属性：
英文名称: IL-27beta
中文名:白细胞介素27β抗体
别 名；cytokine
receptor; EBI3; EBV induced gene 3 protein; EBV-induced gene 3 protein; Epstein
Barr virus induced 3; Epstein Barr virus induced gene 3; Epstein Barr virus
induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein; IL 27
subunit beta; IL 27B; IL-27 subunit beta; IL-27B; IL27 subunit; IL27 subunit
beta; IL27B; IL27B_HUMAN; interleukin 27 subunit beta; Interleukin-27 subunit
beta.
研究领域；细胞生物 免疫学 细菌及病毒
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；23, 50kDa
细胞定位；细胞浆 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EBI3/IL-27beta: 121-229/229
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Epstein-Barr virus-induced gene 3 (Ebi3) is a
widely expressed homolog to the interleukin IL-12 p40 subunit protein that
forms a heterodimer with either IL-12 p35 or an IL-12 p35 homolog, p28, to
create a new cytokine (IL-27). Ebi3 may function to antagonize IL-12 and to
inhibit the development of a Th1 immune response. Ebi3 is strongly expressed
in Hodgkin and Reed-Sternberg cells, independently of the EBV status of the
tumor cells. Ebi2 is expressed in B-lymphocytes and lymphoid tissues and may
function in the modulation of the immune system. Out of the nine genes that
are induced by the Epstein-Barr virus, Ebi2 exhibits the highest levels of
up-regulation. In addition, Ebi2 may play a role mediating normal lymphocyte
functions. Cytokine with pro- and anti-inflammatory
properties, that can regulate T-helper cell development, suppress T-cell
proliferation, stimulate cytotoxic T-cell activity, induce isotype switching
in B-cells, and that has diverse effects on innate immune cells. Among its
target cells are CD4 T-helper cells which can differentiate in type 1
effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper
T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4
T-cells. It also strongly synergizes with IL-12 to trigger
interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the
cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor
activity as well as its antiangiogenic activity with activation of production
of antiangiogenic chemokines. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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