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白细胞介素12辫40抗体
产物名称 | 英文名称 | 货号 |
白细胞介素12p40抗体 | IL12 p40 | GOY-01K2596 |
商品属性：
英文名称: IL12 p40
中文名:白细胞介素12p40抗体
别 名；CLMF; CLMF p40;
CLMF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL 12 subunit
p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN;
interleukin 12 beta chain; Interleukin 12 p40; Interleukin 12 subunit beta;
Interleukin 12B; Interleukin-12 subunit beta; natural killer cell stimulatory
factor 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40.
研究领域；细胞生物 免疫学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；Rat, (predicted: Human, Mouse, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；46kDa
细胞定位；分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human IL12 p40: 201-300/328
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
This gene encodes a subunit of interleukin 12, a
cytokine that acts on T and natural killer cells, and has a broad array of
biological activities. Interleukin 12 is a disulfide-linked heterodimer
composed of the 40 kD cytokine receptor like subunit encoded by this gene,
and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated
macrophages that serve as an essential inducer of Th1 cells development. This
cytokine has been found to be important for sustaining a sufficient number of
memory/effector Th1 cells to mediate long-term protection to an intracellular
pathogen. Overexpression of this gene was observed in the central nervous
system of patients with multiple sclerosis (MS), suggesting a role of this
cytokine in the pathogenesis of the disease. The promoter polymorphism of
this gene has been reported to be associated with the severity of atopic and
non-atopic asthma in children. [provided by RefSeq, Jul 2008] Cytokine that can act as a growth factor for
activated T and NK cells, enhance the lytic activity of
NK/lymphokine-activated killer cells, and stimulate the production of
IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin,
an heterodimeric cytokine which functions in innate and adaptive immunity.
IL-23 may constitute with IL-17 an acute response to infection in peripheral
tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1
and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather
than naive T-cells and promotes production of proinflammatory cytokines.
IL-23 induces autoimmune inflammation and thus may be responsible for
autoimmune inflammatory diseases and may be important for tumorigenesis. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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