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免疫球蛋白顿重链保守区抗体
商品属性：
货号 | 产物名称 | 规格 |
GOY-01K1212 | 免疫球蛋白D重链保守区抗体 | 50ul |
GOY-01K1212 | 免疫球蛋白D重链保守区抗体 | 100ul |
GOY-01K1212 | 免疫球蛋白D重链保守区抗体 | 200ul |
英文名称: IGHD
中文名称: 免疫球蛋白D重链保守区抗体
别 名；IGHD; Constant region of heavy chain of IgD;
Ig delta chain C region; Ig delta chain C region secreted form; IgD; Igh-5;
Immunoglobulin delta; Immunoglobulin heavy constant delta; IGHD_HUMAN;
Immunoglobulin heavy delta chain.
研究领域；细胞生物 免疫学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted: Human, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；42kDa
细胞定位；细胞膜 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH conjugated synthetic
peptide derived from human IGHD: 51-150/384
亚 型；IgG
纯化方法；affinity purified by Protein A
缓 冲 液；0.01M TBS(pH7.4) with 1% BSA,
0.03% Proclin300 and 50% Glycerol.
注意事项；This product as supplied is
intended for research use only, not for use in human, therapeutic or diagnostic
applications.
产物介绍 Ig delta chain C region is an
allelic product of the human IGHD gene. The two known IGHD alleles, IGHD*01 and
IGHD*02, respectively produce isoforms 1, a secreted protein, and 2, a
single-pass type I membrane protein. A member of the adaptive immune system,
IgD antibodies are monomers expressed by activated B cells. Containing 3
Ig-like (immunoglobulin-like) domains, IgD chain C is located on chromosome 14
within the human heavy chain locus, lying on the 3’side of the IgM chain C region from the V-D-J cassette. Polyadenylation at
certain sites along the heavy chain locus likely effects the mechanism that
determines the alternative splicing event which results in the expression of
either IgD chain C or IgM chain C. Some studies have suggested that antigenic
coactivation of IgD+ B cells can have a negative influence on bone resorption
during infectious events.
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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