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甲状旁腺功能亢进蛋白2/细胞分裂周期73抗体
产物名称 | 英文名称 | 货号 |
甲状旁腺功能亢进蛋白2/细胞分裂周期73抗体 | HRPT2 | GOY-01K1613 |
商品属性：
英文名称: HRPT2
中文名:甲状旁腺功能亢进蛋白2/细胞分裂周期73抗体
别 名；C1orf28; CDC 73;
CDC73; Cell division cycle 73; Cell division cycle 73 Paf1/RNA polymerase II
complex component homolog; Cell division cycle protein 73 homolog; FLJ23316;
HPT-JT; HRPT 2; Hyperparathyroidism 2 (with jaw tumor); Hyperparathyroidism 2;
Hyperparathyroidism 2 protein; Parafibromin; CDC73_HUMAN.
研究领域；肿瘤 细胞生物 信号转导 细胞周期蛋白 转录调节因子 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；60kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HRPT2: 61-160/531
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The HRPT2 gene product, parafibromin, is a tumor
suppressor protein that is part of the human Paf1 complex. The yeast
counterpart to this complex is part of the RNA polymerase II complex as well,
and is important for histone modification and connections to
posttranscriptional events. Human parafibromin also associates with the RNA
polymerase II large subunit. Tumor suppressor probably involved in
transcriptional and post-transcriptional control pathways. May be involved in
cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
Component of the PAF1 complex (PAF1C) which has multiple functions during
transcription by RNA polymerase II and is implicated in regulation of
development and maintenance of embryonic stem cell pluripotency. PAF1C
associates with RNA polymerase II through interaction with POLR2A CTD
non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is
involved in transcriptional elongation, acting both indepentently and
synergistically with TCEA1 and in cooperation with the DSIF complex and
HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes.
PAF1C is involved in hematopoiesis and stimulates transcriptional activity of
KMT2A/MLL1; it promotes leukemogenesis through association with
KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and
KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as
ubiquitination of histone H2B and methylation on histone H3 'Lys-4'
(H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
and the E2 enzyme UBE2A or UBE2B to chromatin which mediate
monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated
H2B ubiquitination is proposed to be coupled to transcription. PAF1C is
involved in mRNA 3' end formation probably through association with cleavage
and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C
associates with viral NS1 protein, thereby regulating gene transcription.
Connects PAF1C with the cleavage and polyadenylation specificity factor
(CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with
Wnt signaling. Involved in polyadenylation of mRNA precursors. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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