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组织相容性抗原顿蚕础1重组兔单克隆抗体
产物名称 | 英文名称 | 货号 |
组织相容性抗原DQA1重组兔单克隆抗体 | HLA-DQA1 | GOY-01K1399 |
商品属性：
英文名称: HLA-DQA1
中文名:组织相容性抗原DQA1重组兔单克隆抗体
别 名；CD; CELIAC1; DC 1
alpha chain; DC alpha; DC-1 alpha chain; DC-alpha; DC1, included; DQ alpha 1
chain; DQ-A1; DQ-DRW9 alpha chain; DQA1_HUMAN; FLJ27088; FLJ27328;
Gluten-sensitive enteropathy (celiac disease); GSE; HLA class II
histocompatibility antigen; HLA class II histocompatibility antigen, DQ alpha 1
chain; HLA class II histocompatibility antigen, DQ(W3) alpha chain; HLA-DCA;
HLA-DQA; HLA-DQA1; HLA-DQA1 major histocompatibility complex, class II, DQ
alpha 1; HLADC histocompatibility type; Immune response antigens HIa, included;
leucocyte antigen DQA1; leukocyte antigen alpha chain; Major histocompatibility
complex, class II, DQ alpha 1; MGC149527; MHC class II antigen; MHC class II
DQA1; MHC class II HLA-D alpha glycoprotein; MHC class II HLA-DQ alpha 1; MHC
class II surface glycoprotein; MHC HLA-DQ alpha; OTTHUMP00000029141;
OTTHUMP00000176885; OTTHUMP00000178551; OTTHUMP00000178552; OTTHUMP00000233817.
研究领域；细胞生物 免疫学 转运蛋白
抗体来源；Rabbit
克隆类型；Monoclonal
克 隆 号8C1
交叉反应；Human,
Mouse, Rat,
产物应用；WB=1:500-2000
IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；26kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HLA-DQA1
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Binds peptides derived from antigens that access
the endocytic route of antigen presenting cells (APC) and presents them on
the cell surface for recognition by the CD4 T-cells. The peptide binding
cleft accomodates peptides of 10-30 residues. The peptides presented by MHC
class II molecules are generated mostly by degradation of proteins that
access the endocytic route, where they are processed by lysosomal proteases
and other hydrolases. Exogenous antigens that have been endocytosed by the
APC are thus readily available for presentation via MHC II molecules, and for
this reason this antigen presentation pathway is usually referred to as
exogenous. As membrane proteins on their way to degradation in lysosomes as
part of their normal turn-over are also contained in the endosomal/lysosomal
compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides,
autophagosomes constitutively fuse with MHC class II loading compartments. In
addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs,
which is an unusual trait of the GI tract. To produce a MHC class II molecule
that presents an antigen, three MHC class II molecules (heterodimers of an
alpha and a beta chain) associate with a CD74 trimer in the ER to form an
heterononamer. Soon after the entry of this complex into the endosomal/lysosomal
system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small
fragment termed CLIP (class-II-associated invariant chain peptide). The
removal of CLIP is facilitated by HLA-DM via direct binding to the
alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class
II molecules until primary high affinity antigenic peptides are bound. The
MHC II molecule bound to a peptide is then transported to the cell membrane
surface. In B cells, the interaction between HLA-DM and MHC class II
molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to
express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification
produces increased proteolysis and efficient peptide loading. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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