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人类免疫缺陷病毒2型/2型艾滋病病毒驳辫41+驳辫160抗体
产物名称 | 英文名称 | 货号 |
人类免疫缺陷病毒2型/2型艾滋病病毒gp41+gp160抗体 | HIV2 gp120 + gp160 | GOY-01K1286 |
商品属性：
英文名称: HIV2 gp120 + gp160
中文名:人类免疫缺陷病毒2型/2型艾滋病病毒gp41+gp160抗体
别 名；Gp120; Gp160;
HIV-2 gp120; HIV2 gp160; HIV2gp120; HIV2gp160; HIV 2; Human immunodeficiency
virus 2; Human Immunodeficiency Virus Type 2; ENV_HV2RO.
研究领域；细菌及病毒
抗体来源；Rabbit
克隆类型；Polyclonal
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from HIV2 gp120 + gp160: 311-380/858
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Human immunodeficiency virus type 2 (HIV2),
orginally isolated from patients in West Africa, is the dominant form of HIV
in West Africa capable of causing the acquired immunodeficiency syndrome
(AIDS). HIV2 is closely related to simian immunodeficiency viruses (SIV).
HIV1 and HIV2 share similarity in their genomes, transmission, clinical
features, immunological effects, and in their action of binding to the same
CD4 cellular receptor, but there are significant differences in the amino
acid and nucleotide sequences of HIV1 and HIV2, especially within their
envelope genes and proteins. Additionally, HIV2 may have a longer incubation
period and may be less pathogenic than HIV1. HIV2 gp36 is a transmembrane
protein located in the envelope of the virus specific to HIV2 that binds to
the putative cellular receptor proteins P45 and P62. Function: The surface protein gp120 (SU) attaches the virus
to the host lymphoid cell by binding to the primary receptor CD4. This
interaction induces a structural rearrangement creating a high affinity
binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar
2 stage receptor-interaction strategy allows gp120 to maintain the highly
conserved coreceptor-binding site in a cryptic conformation, protected from
neutralizing antibodies. Since CD4 also displays a binding site for the
disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In
that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing
major conformational changes in gp120. TXN, another PDI family member could
also be involved in disulfide rearrangements in Env during fusion. These
changes are transmitted to the transmembrane protein gp41 and are thought to
activate its fusogenic potential by unmasking its fusion peptide. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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