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亨廷顿(舞蹈症)相互作用蛋白1抗体
产物名称 | 英文名称 | 货号 |
亨廷顿(舞蹈症)相互作用蛋白1抗体 | HIP1 | GOY-01K2300 |
商品属性：
英文名称: HIP1
中文名:亨廷顿(舞蹈症)相互作用蛋白1抗体
别 名；Huntingtin
Interacting Protein HIP1; HIP I; HIP-1; HIP-I; hip1; HIP1/PDGFRB fusion gene;
HIP1/PDGFRB fusion gene, included; HIP1_HUMAN; HIPI; Huntingtin interacting
protein 1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I;
ILWEQ; KIAA4113; MGC126506; MGC27616; mKIAA4113.
研究领域；细胞生物 神经生物学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；116kDa
细胞定位；细胞核 细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HIP1: 401-500/1037
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Huntington disease is associated with the
expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene
product huntingtin. HIP1 (huntingtin-interacting protein 1), a
membrane-associated protein, binds specifically to the N-terminus of human
huntingtin. HIP1 is ubiquitously expressed in different brain regions at low
levels, and exhibits nearly identical subcellular fractionation as
huntingtin. The huntingtin-HIP1 interaction is restricted to the brain and is
inversely correlated to the polyglutamine length in the huntingtin,
suggesting that loss of normal huntingtin-HIP1 interaction may compromise the
membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic
multidomain protein with a C-terminal Actin-binding domain, a central
coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be
involved in vesicle trafficking; the structural integrity of HIP1 is crucial
for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic
member of the HIP gene family that is expressed in the brain and shares a
similar subcellular distribution pattern with HIP1. However, HIP12 differs
from HIP1 in its pattern of expression at both the mRNA and protein level.
HIP12 does not directly interact with huntingtin but can interact with HIP1. Plays a role in clathrin-mediated endocytosis and
trafficking. Involved in regulating AMPA receptor trafficking in the central
nervous system in an NMDA-dependent manner. Enhances androgen receptor
(AR)-mediated transcription. May act as a proapoptotic protein that induces
cell death by acting through the intrinsic apoptosis pathway. Binds
3-phosphoinositides (via ENTH domain). May act through the ENTH domain to
promote cell survival by stabilizing receptor tyrosine kinases following
ligand-induced endocytosis. May play a functional role in the cell filament
networks. May be required for differentiation, proliferation, and/or survival
of somatic and germline progenitors. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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