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多聚腺苷酸因子颁濒辫1蛋白抗体
产物名称 | 英文名称 | 货号 |
多聚腺苷酸因子Clp1蛋白抗体 | HEAB | GOY-01K4593 |
商品属性：
英文名称: HEAB
中文名:多聚腺苷酸因子Clp1蛋白抗体
别 名；ATP/GTP binding protein;
CLP 1; clp1; CLP1 cleavage and polyadenylation factor I subunit homolog; CLP1,
cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae); CLP1,
yeast, homolog of; CLP1_HUMAN; hClp1; Homolog of yeast CFIA subunit Clp1p;
Polynucleotide kinase Clp1; Pre mRNA cleavage complex II protein Clp1; Pre-mRNA
cleavage complex II protein Clp1.
研究领域；细胞生物 免疫学 染色质和核信号 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Cow, Horse, Rabbit, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；48kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HEAB: 1-100/425
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
HEAB is a 425 amino acid nuclear protein that
belongs to the Clp1 family. Utilizing magnesium, manganese or nickel as
cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups
of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA
splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and
TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene
encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D;
mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB
exists as two isoforms due to alternative splicing events. Polynucleotide kinase that can phosphorylate the
5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA
(ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids.
dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of
a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component.
Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component
of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of
the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a
prerequisite for the subsequent ligation of the two exon halves and the
production of a mature tRNA. Component of the pre-mRNA cleavage complex II
(CF-II), which seems to be required for mRNA 3'-end formation. Also
phosphorylates the 5'-terminus of exogenously introduced short interfering
RNAs (siRNAs), which is a necessary prerequisite for their incorporation into
the RNA-induced silencing complex (RISC). However, endogenous siRNAs and
microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by
DICER1 already contain a 5'-phosphate group, so this protein may be
dispensible for normal RNA-mediated gene silencing. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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