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结合球蛋白β抗体
产物名称 | 英文名称 | 货号 |
结合球蛋白β抗体 | Haptoglobin beta | GOY-01K0544 |
商品属性：
英文名称: Haptoglobin beta
中文名:结合球蛋白β抗体
别 名；Binding peptide;
BP antibody Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta;
Haptoglobin; Haptoglobin beta chain; Haptoglobin beta polypeptide; Haptoglobin,
alpha polypeptide; HP antibody HP2ALPHA2; HPA1S; HPT_HUMAN; MGC111141; Zonulin.
研究领域；心血管 免疫学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；Human, (predicted: Mouse, Rat, Dog, Cow, Horse, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；27/43kDa
细胞定位；分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Haptoglobulin beta: 311-406/406
亚 型；IgG
纯化方法；affinity purified
by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Haptoglobin (Hp) is a blood plasma protein that
functions to bind free Hemoglobin that has been released from erythrocytes,
thereby inhibiting its oxidative activity. During this process, Haptoglobin
sequesters the iron within Hemoglobin, preventing iron-utilizing bacteria
from benefitting from hemolysis. This function suggests that Haptoglobin
concentrations may increase in response to inflammation. The resulting
Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial
system. Due to cleavage of a common precursor protein during protein
synthesis, Haptoglobin consists of two ? and two ∫ chains, connected by disulfide bridges. In human,
Haptoglobin exists in two allelic forms designated Haptoglogin 1 (Hp1) and
Haptoglobin 2 (Hp2), where Hp2 is the result of a partial Hp1 gene
duplication. There are three known phenotypes of human Haptoglobin: Hp1-1,
Hp2-1 and Hp2-2, which may be associated with diabetes and cardiovascular
disease pathology and a susceptibility to Parkinson’s
and Crohn’s disease. Haptoglobin levels are useful in
diagnosing hemolytic anemia, the abnormal breakdown of red blood cells.
Haptoglobin is expressed in mammalian hepatocytes as well as other tissues
such as skin, lung and kidney. As a result of hemolysis, hemoglobin is found to
accumulate in the kidney and is secreted in the urine. Haptoglobin captures,
and combines with free plasma hemoglobin to allow hepatic recycling of heme
iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial;
Antioxidant, has antibacterial activity and plays a role in modulating many
aspects of the acute phase response. Hemoglobin/haptoglobin complexes are
rapidely cleared by the macrophage CD163 scavenger receptor expressed on the
surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin,
plays a role in intestinal permeability, allowing intercellular tight
junction disassembly, and controlling the equilibrium between tolerance and
immunity |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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