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骋蛋白偶联受体罢骋搁7蛋白抗体
产物名称 | 英文名称 | 货号 |
G蛋白偶联受体TGR7蛋白抗体 | GPCR TGR7 | GOY-01K4583 |
商品属性：
英文名称: GPCR TGR7
中文名:G蛋白偶联受体TGR7蛋白抗体
别 名；Beta-alanine
receptor; G-protein coupled receptor TGR7; Mas-related G-protein coupled
receptor member D; MRGD; MRGPRD; MRGRD; TGR7; MRGRD_HUMAN.
研究领域；细胞生物 免疫学 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；36kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human GPCR TGR7: 101-200/321
<Extracellular>
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Mas-related G protein-coupled receptors are
sensory neuron-specific G protein-coupled receptors that are usually involved
in the development and function of nociceptive neurons and may also regulate
the sensation or modulation of pain. MRGD (MAS-related GPR, member D), also
known as MRGPRD or TGR7, is a 321 amino acid multi-pass membrane protein that
belongs to the G-protein coupled receptor 1 family and the Mas subfamily.
MRGD is suggested to function specifically as a receptor for beta-alanine, a
naturally occurring beta amino acid. Beta-alanine induces Ca2+ influx and
decreases forskolin-stimulated cAMP production in cells expressing MRGD.
Neurons of outer epidermis that express MRGD act as nociceptors in which they
respond indirectly to external stimuli by detecting ATP release in the skin.
MRGD is encoded by a gene located on human chromosome 11q13.2. Function: May regulate nociceptor function and/or
development, including the sensation or modulation of pain. Functions as a
specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses
specifically evoked Ca(2+) influx in cells expressing the receptor.
Beta-alanine decreases forskolin-stimulated cAMP production in cells
expressing the receptor, suggesting that the receptor couples with G-protein
G(q) and G(i). |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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