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麦角蛋白抗体
产物名称 | 英文名称 | 货号 |
麦角蛋白抗体 | Gliadin | GOY-01K0608 |
商品属性：
英文名称: Gliadin
中文名:麦角蛋白抗体
别 名；Celiac disease;
gliadin - wheat. 麦醇溶蛋白;
产物类型植物抗体
研究领域；糖蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；34kDa
细胞定位；细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from wheat Gliadin: 231-296/296
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Gliadin is a glycoprotein that, along with
glutenin, plays a role in the formation of gluten, an ergastic amorphous
mixture of proteins found in wheat, rye, and barley. Gluten is responsible
for the elasticity of kneaded dough, which allows it to be leavened. Gliadin
is approximately 60% soluble in ethanol and contains only intramolecule
disulfide links. Gliadin is also found in a variety of foods as well as in
beer, along with the glycoprotein Hordein. Induction of zonulin release in
intestinal epithelial cells is triggered by Gliadin. This causes an
activation of the zonulin pathway by PKC mediated cytoskeleton reorganization
and tight junction opening leads to a rapid increase in intestinal
permeability to macromolecules. Individuals with disorders such as celiac
disease or Crohn's disease are sensitive to Gliadin since they lack the
enzyme necessary for its digestion and can not tolerate it in their diet. Celiac disease is associated with a CD4+ T-cell
response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC
molecules. These epitopes are present in a 33-mer peptide of wheat
alpha-gliadin, residues 56-88, which is resistant to digestion and forms a
substrate for tissue transglutaminase (TG2), generating the glutamic acid residues
essential for binding to HLA-DQ2. The alcohol soluble proteins (prolamins)
from wheat, rye, barley and oats produce the harmful effect of coeliac
disease or gluten sensitive enteropathy in humans by causing characteristic
changes in the intestinal mucosa. Patients so affected must avoid eating
these grains and replace them with rice, corn, potatoes, etc. Many
gluten-free foods are produced industrially, thus several immunoassays have
been developed for determination of gliadin in supposedly gluten-free foods. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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