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骋别尘颈苍8蛋白抗体
产物名称 | 英文名称 | 货号 |
Gemin8蛋白抗体 | Gemin 8 | GOY-01K2528 |
商品属性：
英文名称: Gemin 8
中文名:Gemin8蛋白抗体
别 名；Gemin-8; FAM51A1;
FLJ20514; FLJ43072; gem (nuclear organelle) associated protein 8.
研究领域；细胞生物 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, )
产物应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；29kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Gemin 8: 1-100/242
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Gemin8 is a 242 amino acid protein encoded by the
mouse gene Gemin8. Gemin8, along with Gemins 2-7 and unrip, is a major
component of the large multiprotein survival of motor neurons (SMN) complex.
The survival of motor neurons (SMN) protein, a product of the disease gene of
the common neurodegenerative disease spinal muscular atrophy, is also part of
the SMN complex. The SMN complex is a modular composition of proteins with
SMN, Gemin8, and Gemin7 in its center. The SMN complex functions as an assembly
machine for small nuclear ribonucleoproteins (snRNPs)-the major components of
the spliceosome. Gemin8 binds directly to SMN and mediates its interaction
with the Gemin6/Gemin7 heterodimer. Importantly, the loss of Gemin6, Gemin7,
and Unrip interaction with SMN as a result of Gemin8 knockdown affects snRNP
assembly by impairing the SMN complex association with Sm proteins but not
with snRNAs. The Gemin6/Gemin7 complex binds to Sm proteins and might help
organize Sm proteins for formation of Sm rings on snRNA targets. Function: Gemin 8 forms a large macromolecular complex which
includes other gemin proteins, SMN (survival motor neuron) protein and Unrip.
This complex is required for assembly of small nuclear ribonucleoproteins
(snRNPs) from Sm proteins and snRNAs. Gemin 8 mediates the binding of SMN
with gemin 6 and gemin 7. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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