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鸟苷酸环化酶激活蛋白2抗体
产物名称 | 英文名称 | 货号 |
鸟苷酸环化酶激活蛋白2抗体 | GCAP2 | GOY-01K1232 |
商品属性：
英文名称: GCAP2
中文名:鸟苷酸环化酶激活蛋白2抗体
别 名；GCAP 2; Guanylate
Cyclase Activating Protein Photoreceptor 2; Guanylate Cyclase Activator 1B;
Guanylin 2; Guanylyl cyclase-activating protein 2; GUC1B_HUMAN; GUCA 2; GUCA1B.
研究领域；细胞生物 神经生物学 结合蛋白 G蛋白偶联受体 G蛋白信号
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；23kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human GCAP2: 21-120/200
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The intracellular stimulation of guanylate cyclase
(GC) by calcium, a key event in the recovery of the dark state of rod
photoreceptors after exposure to light, is mediated by guanylate
cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins
belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein
that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod
and cone photoreceptor outer segments where phototransduction occurs. In
contrast to other calcium-binding proteins from the calmodulin superfamily,
the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular
cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to
be more than 90% similar, consisting of 201 to 205 amino acids and containing
three identically conserved calcium-binding sites. A related protein, GCAP2,
is detectable only in the retina and results from a gene duplication event.
The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1. Stimulates guanylyl cyclase 1 (GC1) and GC2 when
free calcium ions concentration is low, and GC1 and GC2 when free calcium
ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a
key event in recovery of the dark state of rod photoreceptors following light
exposure. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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