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Ⅲ型纤维连接蛋白域蛋白3础抗体
产物名称 | 英文名称 | 货号 |
Ⅲ型纤维连接蛋白域蛋白3A抗体 | FNDC3A | GOY-01K2371 |
商品属性：
英文名称: FNDC3A
中文名:Ⅲ型纤维连接蛋白域蛋白3A抗体
别 名；Fibronectin type
III domain containing protein 3a; FNDC3; HUGO; KIAA0970; FND3A_HUMAN.
研究领域；细胞生物 发育生物学 细胞粘附分子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；125kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human FNDC3A: 501-600/1198
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
FNDC3A is a 1,134 amino acid protein that belongs
to the FNDC3 family of proteins. FNDC3A contains an N-terminal proline-rich
region, nine fibronectin type-III domains (none of which contain an RGD
sequence) and a hydrophobic C-terminal transmembranous helix. Expressed in a
wide variety of tissues, FNDC3A localizes to Golgi vesicles and to the
developing acrosome of spermatids. FNDC3A is believed to function in glycosaminoglycan
and collagen synthesis. In mice, a mutation in the gene encoding FNDC3A
causes male sterility due to defective adhesion between Sertoli cells and
spermatids in the seminiferous epithelium. This suggests that FNDC3A plays an
important role in spermatogenesis, possibly mediating or maintaining the
adhesion between Sertoli cells and spermatids. Function: FNDC3A is a member of a three-gene family in mice.
It is expressed in several tissues including testis, and encodes a novel
protein composed of a proline-rich amino-terminus, nine fibronectin type-III
domains, and a hydrophobic carboxy-terminus. The proline-rich region of each
family member contains conserved amino acids that include a PPGY consensus
binding site for type I WW domain containing proteins. The hydrophobic
carboxy-terminus is similar to that found in 'tail-anchored' proteins,
integral membrane proteins that are localized to the cytosolic face of the
endoplasmic reticulum. Immunohistochemical staining has shown that FNDC3A
localizes to the acrosome of spermatids, as well as to Leydig cells in the
mouse testis. FNDC3A may be involved in mediating spermatid-Sertoli adhesion
during mouse spermatogenesis and mutation of FNDC3A is the cause of male
sterility in sys mice. FNDC3A has also been found to be overexpressed in
human odontoblasts. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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