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“衰老关键蛋白”抗体
产物名称 | 英文名称 | 货号 |
“衰老关键蛋白”抗体 | Fibulin 1 | GOY-01K0092 |
商品属性：
英文名称: Fibulin 1
中文名:“衰老关键蛋白”抗体
别 名；Basement membrane
protein 90; BM 90; FBLN; FBLN1; FIBL 1; FIBL1; Fibulin 1; FBLN1_HUMAN; FIBL-1;
Fibulin-1.
研究领域；肿瘤 心血管 细胞生物 免疫学 内分泌病
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；74kDa
细胞定位；细胞外基质 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Fibulin 1: 501-600/703
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Fibulin-1 is an extracellular matrix protein often
associated with fibronectin (FN) in vivo. Fibulin-1 was found to have
pronounced inhibitory effects on the cell attachment and spreading promoted
by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell
types on FN substrata. For example, the FN-dependent haptotactic motility of
breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma
(A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese
hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to
FN-coated Boyden chamber membranes. Cells transfected to overproduce
fibulin-1 displayed reduced velocity, distance of movement and persistence
time on FN substrata. Similarly, the incorporation of fibulin-1 into
FN-containing type I collagen gels inhibited the invasion of endocardial
cushion mesenchymal cells migrating from cultured embryonic heart explants.
By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no
effect on the migration of endocardial cushion cells. Function: Incorporated into fibronectin-containing matrix
fibers. May play a role in cell adhesion and migration along protein fibers
within the extracellular matrix (ECM). Could be important for certain
developmental processes and contribute to the supramolecular organization of
ECM architecture, in particular to those of basement membranes. Has been
implicated in a role in cellular transformation and tumor invasion, it
appears to be a tumor suppressor. May play a role in haemostasis and
thrombosis owing to its ability to bind fibrinogen and incorporate into
clots. Could play a significant role in modulating the neurotrophic
activities of APP, particularly soluble APP. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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