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贰驰础3蛋白抗体
产物名称 | 英文名称 | 货号 |
EYA3蛋白抗体 | EYA3 | GOY-01K1127 |
商品属性：
英文名称: EYA3
中文名:EYA3蛋白抗体
别 名；AI844637;
DKFZp686C132; EYA3; EYA3_HUMAN; Eyes absent 3; Eyes absent 3 homolog
(Drosophila); Eyes absent homolog 3; OTTMUSP00000010370; RP11-460I13.4;
RP23-442A20.1.
研究领域；细胞生物 发育生物学 信号转导 干细胞 转录调节因子 激酶和磷酸酶 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；63kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH conjugated
synthetic peptide derived from human EYA3: 371-470/573
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
EYA3 is a 573 amino acid protein that localizes to
both the nucleus and the cytoplasm and is one of several mammalian homologs
of the Drosophila Eya (eyes absent) protein. Existing as two alternatively
spliced isoforms, EYA3 possesses magnesium-catalyzed phosphatase activity and
is thought to play a role in transcriptional regulation during organogenesis.
Specifically, EYA3 interacts with proteins such as Six1 and, via this
interaction, functions to activate the expression of genes that are involved
in cellular proliferation and organ development. Upon DNA damage, EYA3 may be
phosphorylated by ATM or ATR. The gene encoding EYA3 maps to chromosome 1,
which spans about 260 million base pairs and comprises nearly 8% of the human
genome. Function: Tyrosine phosphatase that specifically
dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142'
phosphorylation of histone H2AX plays a central role in DNA repair and acts
as a mark that distinguishes between apoptotic and repair responses to
genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX,
promoting the recruitment of DNA repair complexes containing MDC1. Its
function as histone phosphatase probably explains its role in transcription
regulation during organogenesis. Coactivates SIX1, and seems to coactivate
SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in
myoblasts by SIX1 is switched to activation through recruitment of EYA3 to
the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity
(By similarity). May be involved in development of the eye. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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