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贰齿翱厂颁1蛋白抗体
产物名称 | 英文名称 | 货号 |
EXOSC1蛋白抗体 | EXOSC1 | GOY-01K0788 |
商品属性：
英文名称: EXOSC1
中文名:EXOSC1蛋白抗体
别 名；3'-5' exoribonuclease
CSL4 homolog; CGI 108; CGI-108; CSL4; CSL4 exosomal core protein homolog; CSL4,
S. cerevisiae, homolog of; Csl4p; EXOS1_HUMAN; Exosc1; Exosomal core protein
CSL4; Exosome complex component csl4; Exosome component 1; hCsl4p; Homolog of
yeast exosomal core protein CSL4; p13; RP11-452K12.9; SKI4; Ski4p.
研究领域；细胞生物 转录调节因子 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；21kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EXOSC1: 61-160/195
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
This gene encodes a core component of the exosome.
The mammalian exosome is required for rapid degradation of AU rich
element-containing RNAs but not for poly(A) shortening. The association of
this protein with the exosome is mediated by protein-protein interactions
with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein
46. [provided by RefSeq, Jul 2008] Function: Non-catalytic component of the RNA exosome complex
which has 3'->5' exoribonuclease activity and participates in a multitude
of cellular RNA processing and degradation events. In the nucleus, the RNA
exosome complex is involved in proper maturation of stable RNA species such
as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products
and non-coding 'pervasive' transcripts, such as antisense RNA species and
promoter-upstream transcripts (PROMPTs), and of mRNAs with processing
defects, thereby limiting or excluding their export to the cytoplasm. The RNA
exosome may be involved in Ig class switch recombination (CSR) and/or Ig
variable region somatic hypermutation (SHM) by targeting AICDA deamination
activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome
complex is involved in general mRNA turnover and specifically degrades
inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'
untranslated regions, and in RNA surveillance pathways, preventing
translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits
(Exo-9) is proposed to play a pivotal role in the binding and presentation of
RNA for ribonucleolysis, and to serve as a scaffold for the association with
catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral
part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain
subunits through contacts with EXOSC6 and EXOSC8. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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