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早期生长反应蛋白4抗体
产物名称 | 英文名称 | 货号 |
早期生长反应蛋白4抗体 | EGR4 | GOY-01K1736 |
商品属性：
英文名称: EGR4
中文名:早期生长反应蛋白4抗体
别 名；AT133; EGR4_HUMAN； Early growth response protein 4; Nerve growth factor induced clone
C; NGFI C; NGFIC; PAT133.
研究领域；细胞生物 神经生物学 转录调节因子 锌指蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other
applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；62kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EGR4: 501-589/589
亚 型；IgG
纯化方法；affinity
purified by Protein A
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Egr-1, Egr-2, Egr-3 and Egr-4 are nuclear
transcription factors belonging to the Egr C2H2-type zinc-finger protein
family and containing three C2H2-type zinc fingers. As immediate early
proteins, Egr transcription factors are rapidly induced by diverse
extracellular stimuli. They are subject to tight differential control through
diverse mechanisms at several levels of regulation: transcriptional;
translational and posttranslational (including glycosylation, phosphorylation
and redox) mechanisms; and protein-protein interaction. Egr-1 binds to the
DNA sequence 5'-CGCCCCCGC-3' (Egr-site), thereby activating transcription of
target genes whose products are required for mitogenisis and differentiation.
Egr-2 binds specific DNA sites located in the promoter region of HoxA4. Egr-2
defects cause congenital hypomyelination neuropathy (also designated
Charcot-Marie-Tooth disease) and Dejerine-Sottas neuropathology (also
designated hereditary motor and sensory neuropathy III). Egr-3 is involved in
muscle spindle development and is expressed in T cells 20 minutes following
activation. Egr-4 binds to the Egr consensus motif GCGTGGGCG, functions as a
transcriptional repressor, and displays autoregulatory activities,
downregulating its own gene promoter in a dose dependent manner. Function: EGR4(Early Growth Response protein 4) is a
zinc-finger transcription factor that activates the transcription of genes
whose products are required for mitogenesis and differentiation. EGR4 is
closely related to nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2,
and EGR3. These four early response (immediate early) proteins all contain
very similar zinc-finger DNA binding domains and five highly homologous
subdomains. EGR4 functionally cooperate with NFAT proteins and induce
expression of IL2 and TNFalpha. Early growth response proteins (EGR) and
nuclear factors of activated T cells (NFAT) form heterodimers and regulate
proinflammatory cytokine gene expression. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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