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牙本质基质蛋白1抗体
产物名称 | 英文名称 | 货号 |
牙本质基质蛋白1抗体 | DMP1 | GOY-01K2035 |
商品属性：
英文名称: DMP1
中文名:牙本质基质蛋白1抗体
别 名；ARHP; ARHR;
AV020965; Dentin matrix acidic phosphoprotein 1; Dentin matrix protein 1;
DENTMAT; DMP 1; Dmp; MGC130441; PP; Serine rich acidic phosphoprotein;
DMP1_HUMAN.
研究领域；细胞生物 发育生物学 信号转导 干细胞 细胞骨架
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；54kDa
细胞定位；细胞核 细胞浆 细胞外基质 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human DMP1: 221-320/513
亚 型；IgG
纯化方法；affinity
purified by Protein A
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
DMP-1 is a member of the small integrin ligand
N-linked glycoprotein family. It is important for the mineralization of bone
and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It
is synthesized by preosteoblasts and contains a large number of acidic
domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where
it functions as a transcriptional regulator for osteoblast-specific gene
activation and induces osteoblast differentiation. During osteoblast
maturation, DMP-1 undergoes a conformational change and becomes
phosphorylated by casein kinase II in response to an influx of calcium ions
to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM)
where it regulates the nucleation of hydroxyapatite and the formation of
calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal
fragments in the ECM of bone and dentin. The protein has also been identified
in bone as a high molecular weight proteoglycan comprised of the N-terminal
DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in
hypomineralized bone. Function: DMP1 is an extracellular matrix protein and a
member of the small integrin binding ligand N-linked glycoprotein family. It
is critical for proper mineralization of bone and dentin, and is present in
diverse cells of bone and tooth tissues. DMP1 contains a large number of
acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell
attachment sequence, and a DNA binding domain. DMP1 may also have a dual
function during osteoblast differentiation. In the nucleus of undifferentiated
osteoblasts the unphosphorylated form acts as a transcriptional component for
activation of osteoblast-specific genes like osteocalcin. During the
osteoblast to osteocyte transition phase it is phosphorylated and exported
into the extracellular matrix, where it regulates nucleation of
hydroxyapatite. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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