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动力蛋白激活蛋白1抗体
产物名称 | 英文名称 | 货号 |
动力蛋白激活蛋白1抗体 | DCTN1/DAP-150 | GOY-01K0337 |
商品属性：
英文名称: DCTN1/DAP-150
中文名:动力蛋白激活蛋白1抗体
别 名；Alternative
names150 kDa dynein associated polypeptide; 150 kDa dynein-associated polypeptide;
DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150;
Dynactin 1 (p150 Glued (Drosophila) homolog); Dynactin 1 (p150 glued homolog
Drosophila); Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; P135; p150 Glued
(Drosophila) homolog; p150 glued; p150 glued homolog; p150(GLUED) DROSOPHILA
HOMOLOG OF; p150-glued; p150glued.
研究领域；肿瘤 细胞生物 神经生物学 信号转导 细胞周期蛋白 转录调节因子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；142kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH conjugated
synthetic peptide derived from human DCTN1/Dynactin 1: 251-350/1278
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Required for the cytoplasmic dynein-driven
retrograde movement of vesicles and organelles along microtubules.
Dynein-dynactin interaction is a key component of the mechanism of axonal
transport of vesicles and organelles. Involvement in disease; Defects in DCTN1 are the
cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as
progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular
disorder. Distal hereditary motor neuronopathies constitute a heterogeneous
group of neuromuscular disorders caused by selective degeneration of motor
neurons in the anterior horn of the spinal cord, without sensory deficit in
the posterior horn. The overall clinical picture consists of a classical
distal muscular atrophy syndrome in the legs without clinical sensory loss.
The disease starts with weakness and wasting of distal muscles of the
anterior tibial and peroneal compartments of the legs. Later on, weakness and
atrophy may expand to the proximal muscles of the lower limbs and/or to the
distal upper limbs. Defects in DCTN1 are a cause of susceptibility to
amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder
affecting upper and lower motor neurons, and resulting in fatal paralysis.
Sensory abnormalities are absent. Death usually occurs within 2 to 5 years.
The etiology is likely to be multifactorial, involving both genetic and
environmental factors. Defects in DCTN1 are the cause of Perry syndrome
(PERRYS); also called parkinsonism with alveolar hypoventilation and mental
depression. Perry syndrome is a neuropsychiatric disorder characterized by
mental depression not responsive to antidepressant drugs or electroconvulsive
therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism
develops later and respiratory failure occurred terminally. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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