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Cullin 4a蛋白抗体
产物名称 | 英文名称 | 货号 |
Cullin 4a蛋白抗体 | Cullin 4A | GOY-01K1880 |
商品属性：
英文名称: Cullin 4A
中文名:Cullin 4a蛋白抗体
别 名；CUL 4A; CUL4A;
Cul4a protein; MGC36573; MGC64071.
研究领域；细胞生物 免疫学 细胞凋亡 合成与降解
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；83kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Cullin 4a: 421-520/759
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Cullins assemble a potentially large number of
ubiquitin ligases by binding to the RING protein ROC1 to catalyse
polyubiquitination, as well as binding to various specificity factors to
recruit substrates. Cullin 4a is an essential component of the SCF
(SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the
ubiquitination of proteins involved in cell cycle progression, signal
transduction and transcription. In the SCF complex, cul4A serves as a rigid
scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul4A may
also contribute to catalysis through positioning of the substrate and the
ubiquitinconjugating enzyme. Cul4A also interacts with RNF7 and is part of a
complex with TIP120A/CAND1, Cyclin E and RBX1. Function: Core component of multiple cullin-RING-based E3
ubiquitin-protein ligase complexes which mediate the ubiquitination and
subsequent proteasomal degradation of target proteins. As a scaffold protein
may contribute to catalysis through positioning of the substrate and the
ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the
complex is dependent on the neddylation of the cullin subunit and is
inhibited by the association of the deneddylated cullin subunit with
TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase
complex depends on the variable substrate recognition component.
DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs
ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required
for histone H3 and histone H4 ubiquitination in response to ultraviolet and
may be important for subsequent DNA repair. DCX(DTL) plays a role in
PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination
of TP53 in response to radiation-induced DNA damage and during DNA
replication. In association with DDB1 and SKP2 probably is involved in
ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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