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肿瘤/睾丸抗原27抗体（高迁移率族蛋白）
产物名称 | 英文名称 | 货号 |
肿瘤/睾丸抗原27抗体（高迁移率族蛋白） | CT27 | GOY-01K1460 |
商品属性：
英文名称: CT27
中文名:肿瘤/睾丸抗原27抗体（高迁移率族蛋白）
别 名；BORIS like
protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27;
CCCTC binding factor (zinc finger protein) like; CCCTC-binding factor; CT27;
CTCF paralog; CTCF T; CTCF-like protein; CTCFL; CTCFL_HUMAN; HMG 1L1; HMGB1L1;
Putative high mobility group protein 1 like 1; Putative high mobility group
protein B1 like 1; Transcriptional repressor CTCFL; Zinc finger protein CTCF-T.
研究领域；肿瘤 免疫学 染色质和核信号 信号转导 转录调节因子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；72kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human BORIS/CT27: 351-450/663
亚 型；IgG
纯化方法；affinity purified
by Protein A
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Testis-specific DNA binding protein responsible
for insulator function, nuclear architecture and transcriptional control,
which probably acts by recruiting epigenetic chromatin modifiers. Plays a key
role in gene imprinting in male germline, by participating in the establishment
of differential methylation at the IGF2/H19 imprinted control region (ICR).
Directly binds the unmethylated H19 ICR and recruits the PRMT7
methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.
This probably leads to recruit de novo DNA methyltransferases at these sites
(By similarity). Seems to act as tumor suppressor. In association with DNMT1
and DNMT3B, involved in activation of BAG1 gene expression by binding to its
promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and
BRCA1 promoters. Function: Testis-specific DNA binding protein responsible
for insulator function, nuclear architecture and transcriptional control,
which probably acts by recruiting epigenetic chromatin modifiers. Plays a key
role in gene imprinting in male germline, by participating in the
establishment of differential methylation at the IGF2/H19 imprinted control
region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7
methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.
This probably leads to recruit de novo DNA methyltransferases at these sites
(By similarity). Seems to act as tumor suppressor. In association with DNMT1
and DNMT3B, involved in activation of BAG1 gene expression by binding to its
promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and
BRCA1 promoters. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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