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丝裂原活化蛋白激酶激酶4抗体
产物名称 | 英文名称 | 货号 |
丝裂原活化蛋白激酶激酶4抗体 | MEK4 | GOY-01K1549 |
商品属性：
英文名称: MEK4
中文名:丝裂原活化蛋白激酶激酶4抗体
别 名；c Jun N terminal
kinase kinase 1; c-Jun N-terminal kinase kinase 1; c-Jun N-terminal kinase
kinase 1; Dual specificity mitogen activated protein kinase kinase 4; Dual
specificity mitogen activated protein kinase kinase 4; Dual specificity
mitogen-activated protein kinase kinase 4; JNK activated kinase 1; JNK
Activated Kinase 1; JNK activating kinase 1; JNK activating kinase 1;
JNK-activating kinase 1; JNKK 1; JNKK; JNKK; JNKK-1; JNKK-1; JNKK1; JNKK1; MAP
kinase kinase 4; MAP kinase kinase 4; MAP2K4; MAPK / ERK kinase 4; MAPK / ERK
kinase 4; MAPK ERK kinase 4; MAPK/ERK kinase 4; MAPKK 4; MAPKK 4; MAPKK-4;
MAPKK-4; MAPKK4; MAPKK4; MEK 4; MEK 4; MEK-4; MEK-4; MEK4; Mitogen Activated
Protein Kinase Kinase 4; MKK 4; MKK-4; MKK-4; MKK4; MP2K4_HUMAN; PRKMK 4; PRKMK
4; PRKMK-4; PRKMK-4; PRKMK4; PRKMK4; SAPK / ERK kinase 1; SAPK / ERK kinase 1;
SAPK ERK kinase 1; SAPK/ERK Kinase 1; SEK 1; SEK1; SEK1; SERK 1; SERK-1;
SERK-1; SERK1; SERK1.
研究领域；肿瘤 细胞生物 免疫学 信号转导 转录调节因子 激酶和磷酸酶
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Cow, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；44kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human MKK4/MAP2K4: 301-399/399
亚 型；IgG
纯化方法；affinity
purified by Protein A
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
Function:
Dual specificity
protein kinase which acts as an essential component of the MAP kinase signal
transduction pathway. Essential component of the stress-activated protein
kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,
is the one of the only known kinase to directly activate the stress-activated
protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they
differ in their preference for the phosphorylation site in the Thr-Pro-Tyr
motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and
MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by
MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in
response to proinflammatory cytokines, while other stimuli activate both
MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is
required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling
pathway is also involved in mitochondrial death signaling pathway, including
the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively
activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11,
MAPK12, MAPK13 and MAPK14.
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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