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环核苷酸门控阳离子通道蛋白β3/颁狈骋-β3抗体
产物名称 | 英文名称 | 货号 |
环核苷酸门控阳离子通道蛋白β3/CNG-β3抗体 | CNGB3 | GOY-01K2676 |
商品属性：
英文名称: CNGB3
中文名:环核苷酸门控阳离子通道蛋白β3/CNG-β3抗体
别 名；ACHM1; ACHM3;
Achromatopsia (rod monochromacy) 3; CNG channel beta-3; CNGB3; CNGB-3_HUMAN;
Cone photoreceptor cGMP-gated cation channel beta-subunit; Cone photoreceptor
cGMP-gated channel subunit beta; Cyclic nucleotide gated channel beta 3; Cyclic
nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel
modulatory subunit; Cyclic nucleotide-gated channel beta-3; RMCH; RMCH1.
研究领域；细胞生物 神经生物学 通道蛋白 细胞膜受体
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；92kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CNGB3: 301-400/809
<Extracellular>
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Cyclic nucleotide-gated (CNG) cation channels are heteromeric
complexes made up of principal alpha and modulatory beta subunits. The alpha
subunits consist of CNG1-3 and form functional cation channels by themselves.
The beta subunits consist of CNG4-6 and, unlike the alpha subunits, do not
form functional channels, but rather modify the properties of channels.
formed by CNG1-3. CNG channels are essential components of olfactory and
visual transduction. CNG proteins are present in cone and rod photoreceptors
and in the pineal gland, and they contribute to modulating arterial blood
pressure. CNG6, also designated cyclic-nucleotide-gated cation channel beta 3
(CNG-beta 3), is an integral membrane protein that can form a
heterooligomeric complex with CNG-3. CNG-beta 3 is activated by cGMP and this
activation leads to the depolarization of rod photoreceptors as a result of
cation channel being opened. CNG-beta 3 is expressed in a small group of
retinal photoreceptor cells and in testis. Mutations in the gene encoding for
CNG-beta 3, can cause achromatopsia, an autosomal recessively inherited
disease characterized by low visual acuity, photophobia, a lack of color
discrimination, and nystagmus. Visual signal transduction is mediated by a
G-protein coupled cascade using cGMP as second messenger. This protein can be
activated by cGMP which leads to an opening of the cation channel and thereby
causing a depolarization of rod photoreceptors. Induced a flickering channel
gating, weakened the outward rectification in the presence of extracellular
calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP
efficiency of the channel when coexpressed with CNGA3 (By similarity).
Essential for the generation of light-evoked electrical responses in the
red-, green- and blue sensitive cones. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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