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氯离子通道调节蛋白1础抗体
产物名称 | 英文名称 | 货号 |
氯离子通道调节蛋白1A抗体 | CLNS1A | GOY-01K0993 |
商品属性：
英文名称: CLNS1A
中文名:氯离子通道调节蛋白1A抗体
别 名；nucleotide
sensitive 1A; Chloride channel; Chloride channel nucleotide sensitive 1A;
Chloride channel regulatory protein; Chloride conductance regulatory protein
ICln; Chloride ion current inducer protein; ClCI; CLNS 1A; Clns1a; CLNS1B;
I(Cln); ICln; ICLN_HUMAN; Methylosome subunit pICln; Reticulocyte pICln
研究领域；心血管 细胞生物 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；26kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CLNS1A/pICln: 21-120/237
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The formation of the spliceosome includes the
assembly of Sm proteins in an ordered manner onto snRNAs. This process is
mediated by the survival of motor neuron (SMN) protein, and is enhanced by
modification of specific arginine residues in the Sm proteins to symmetrical
dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by
the methylosome, a complex comprised of the type II methyltransferase PRMT5
(also designated Jak-binding protein 1, JBP1), pICln, and two novel factors.
PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG)
domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of
SnRNP assembly by preventing specific interactions between Sm proteins required
for the formation of the Sm core. pICln is a highly conserved, ubiquitously
expressed protein that localizes primarily to the cytoplasm, and may play a
role as a swelling-activated anion channel or a channel regulator in addition
to its function in the methylosome. The gene encoding human pICln maps to
chromosome 11q14.1. The interaction with Sm proteins inhibits their
assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding
of survival motor neuron protein (SMN) to Sm proteins. May participate in
cellular volume control by activation of a swelling-induced chloride
conductance pathway. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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