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氯离子通道蛋白5抗体
产物名称 | 英文名称 | 货号 |
氯离子通道蛋白5抗体 | Chloride Channel 5 | GOY-01K1075 |
商品属性：
英文名称: Chloride Channel 5
中文名:氯离子通道蛋白5抗体
别 名；Chloride channel
protein 5; Chloride transporter ClC-5; ClC-5; CLC5; CLCK2; CLCN5; CLCN5_HUMAN;
DENTS; H(+)/Cl(-) exchange transporter 5; hCIC-K2; NPHL1; NPHL2; XLRH; XRN.
研究领域；肿瘤 神经生物学 信号转导 通道蛋白 细胞膜受体 新陈代谢
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；83kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Chloride Channel 5/CLC5:
1-100/746
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This product
as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The family of voltage-dependent chloride channels
(CLCs) regulate cellular trafficking of chloride ions, a critical component
of all living cells. CLCs regulate excitability in muscle and nerve cells,
aid in organic solute transport and maintain cellular volume. The genes
encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32,
Xp22.3, Xp11.23-p11.22, 1p36 and 16p13, respectively. CLC1 is highly
expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to
myotonia, an inheritable disorder characterized by muscle stiffness and renal
salt wasting. CLC2 is highly expressed in the epithelia of several organs including
lung, which suggests CLC2 may be a possible therapeutic target for cystic
fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while
CLC4 expression is evident in skeletal and cardiac muscle as well as brain.
Mutations in the gene encoding CLC5 lead to Dent’s disease, a renal disorder characterized by
proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in
several tissues including testis, kidney, brain and muscle. Proton-coupled chloride transporter. Functions as
antiport system and exchanges chloride ions against protons. Important for
normal acidification of the endosome lumen. May play an important role in
renal tubular function. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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