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础罢笔依赖的解旋酶颁贬顿1抗体
产物名称 | 英文名称 | 货号 |
ATP依赖的解旋酶CHD1抗体 | CHD1 | GOY-01K4677 |
商品属性：
英文名称: CHD1
中文名:ATP依赖的解旋酶CHD1抗体
别 名；ATP dependent helicase
CHD 1; ATP dependent helicase CHD1; ATP-dependent helicase CHD1; CHD 1; CHD-1;
CHD1; CHD1_HUMAN; Chromodomain helicase DNA binding protein 1;
Chromodomain-helicase-DNA-binding protein 1; DKFZp686E2337; OTTHUMP00000222625.
研究领域；细胞生物 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；197kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CHD1: 151-250/1710
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Chromodomains participate in the recognition of
lysine-methylated histone tails and nucleic acids. The CHD1 protein, named
for its chromo-domain, ATPase helicase-like domain and DNA-binding domain,
functions as an ATP-utilizing chromatin assembly factor. Unlike HP1 and Polycomb
proteins that use single chromodomains to bind to their respective methylated
Histone H3 tails, the two chromodomains of CHD1 cooperate to associate with
one methylated H3 tail. Unique inserts within chromodomain 1 of CHD1 block
the expected site of H3 tail binding seen in HP1 and Polycomb, and instead
direct H3 binding to a groove at the interchromodomain junction. The human
CHD1 gene maps to 5q21.1, and encodes a 1,709 amino acid deduced protein that
shares 95.5% identity with the 1,711 amino acid mouse Chd1 polypeptide. Function: ATP-dependent chromatin-remodeling factor which
functions as substrate recognition component of the transcription regulatory
histone acetylation (HAT) complex SAGA. Regulates polymerase II
transcription. Also required for efficient transcription by RNA polymerase I,
and more specifically the polymerase I transcription termination step.
Regulates negatively DNA replication. Not only involved in
transcription-related chromatin-remodeling, but also required to maintain a
specific chromatin configuration across the genome. Is also associated with
histone deacetylase (HDAC) activity (By similarity). Required for the
bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP
complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing
in part through physical bridging of spliceosomal components to H3K4me3.
Required for maintaining open chromatin and pluripotency in embryonic stem
cells. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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