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颁骋骋结合蛋白1抗体
产物名称 | 英文名称 | 货号 |
CGG结合蛋白1抗体 | CGGBP1 | GOY-01K1301 |
商品属性：
英文名称: CGGBP1
中文名:CGG结合蛋白1抗体
别 名；20 kDa CGG
binding protein; 20 kDa CGG-binding protein; CGBP1_HUMAN; CGG binding protein
1; CGG triplet repeat binding protein 1; CGG triplet repeat-binding protein 1;
CGG-binding protein 1; CGGBP 1; CGGBP; Cggbp1; OTTHUMP00000213853;
OTTHUMP00000213877; p20 CGG binding protein; p20 CGGBP; p20 CGGBP DNA binding
protein; p20-CGGBP DNA-binding protein.
研究领域；细胞生物 信号转导 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, )
产物应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理论分子量；19kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CGGBP1: 1-100/167
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Fragile X syndrome is the most frequent form of
inherited mental retardation and is the result of transcriptional silencing
of the FMR1 (fragile X mental retardation) gene on the X chromosome. The FMR1
gene contains a distinct CpG dinucleotide repeat located in the 5’-untranslated region of the gene which, in fragile X
syndrome, is substantially amplified and subject to extensive methylation and
enhanced transcriptional silencing. CGGBP1 (CGG triplet repeat binding
protein 1), also known as CGGBP or p20-CGGBP, is a 167 amino acid nuclear
protein that influences FMR1 expression. Highly expressed in thymus,
placenta, lymph nodes, cerebral cortex and cerebellum, CGGBP1 binds to the 5’ (CGG)n-3’ repeat in the promotor of the
FMR1 gene and positively regulates expression of the FMR1 protein. Binding of
CGGBP1 to the FMR1 promoter is inhibited by cytosine-specific DNA methylation
of the protein binding motif, suggesting that CGGBP1 activity is silenced in
FMR1-affected individuals. Function: Binds to nonmethylated 5'-d(CGG)(n)-3'
trinucleotide repeats in the FMR1 promoter. May play a role in regulating
FMR1 promoter. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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