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颁顿299抗体
产物名称 | 英文名称 | 货号 |
CD299抗体 | CD299 | GOY-01K2024 |
商品属性：
英文名称: CD299
中文名:CD299抗体
别 名；C type lectin
domain family 4 member M; C type lectin domain family 4, member M; C-type
lectin domain family 4, member M; CD209 antigen like protein 1; CD209
antigen-like; CD209L; CD209L1; CD299 antigen; CLEC4M; DC SIGN related protein;
DC SIGN2; DC SIGNR; DC-SIGN related protein; DC-SIGN2; DC-SIGNR; DCSIGN-related
protein; DCSIGNR; dendritic cell specific ICAM-3-grabbing nonintegrin 2;
Dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; L SIGN;
Liver/lymph node specific ICAM 3 grabbing nonintegrin; Liver/lymph
node-specific ICAM3-grabbing nonintegrin; LSIGN; Mannose binding C-type lectin
DC-SIGNR; MGC129964; MGC47866; CLC4M_HUMAN.
研究领域；细胞生物 免疫学 淋巴细胞
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；45kDa
细胞定位；细胞膜 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CD299: 101-200/399
<Extracellular>
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Dendritic cells (DC) play a primary role in the
immune system as antigen presenting cells. A key molecule, dendritic cell
specific ICAM3 grabbing nonintegrin (DC SIGN1), is involved in regulating
interactions between DC and resting T cells, including antigen presentation
to T cells and enhancement of transinfection of CD4+ T cells by HIV 1.
Efforts to identify additional type II membrane proteins resulted in the
isolation of a related molecule named CD299, also known as DC SIGNR (DC SIGN
Related), DC SIGN2, CD209L, and L SIGN (liver/lymph nodespecific ICAM3
grabbing nonintegrin). CD299 is located on Human chromosome 19p13.3 and
shares 73-80% amino acid identity with DC SIGN1. Its structure is similar to
DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion,
including ICAM3 and HIV 1 gp120. CD299 is polymorphic, since allelic
variations of the exon 4 encoded sequence have been isolated. This is further
supported by a study demonstrating the ability to isolate a large repertoire
of CD299 transcripts largely the result of alternative splicing of the 7
coding exons. CD299 is primarily transcribed in the liver and lymph nodes but
not in monocyte derived DC. Expression of CD299 is restricted to endothelial
cells derived from liver sinusoids, lymph nodes sinuses, and capillaries,
although variable expression in placenta and some monocytic cell lines has
also been reported, including both membrane and soluble isoforms of the
protein. Function: Probable pathogen-recognition receptor involved in
peripheral immune surveillance in liver. May mediate the endocytosis of
pathogens which are subsequently degraded in lysosomal compartments. Probably
recognizes in a calcium-dependent manner high mannose N-linked
oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120,
HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS
coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like
carbohydrates. Is presumably a coreceptor for the SARS coronavirus. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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